Mar. 21, 2022
Potassium cinnamate also known as 3-phenyl-2-acrylic acid potassium or potassium cinnamate, is white crystalline powder, soluble in water, slightly soluble in ethanol, with natural cinnamon aroma. Potassium cinnamate USES A new type of natural food preservative, widely used in medicine, agriculture, and food.
As a natural food preservative, potassium cinnamate has the following characteristics:
Strong antibacterial ability, especially to cause food spoilage of mold, bacteria, and Yeasts, its effective concentration of inhibition of mold is 0.05-0.1%, the general dosage is 0.01-0.02%, the effective concentration of inhibition of bacteria is 0.01-0.1%. The main targets include PSEUDOMONAS, micrococcus, Bacillus, Enterobacteriaceae, vibrios, Halophilic Bacilli, aerophilic bacteria, lactobacillus, lactic acid bacteria, aflatoxins, escherichia coli, proteus, lactobacillus casei, Casei, bacillus cereus, aerobic bacillus, gram-negative, positive bacilli, botulinum and so on. At the same time, potassium cinnamate is not limited by Ph, Ph value between 2-7 antibacterial effect is also quite good, and antibacterial effect does not change due to the fluctuation of Ph, can be widely used in all kinds of food.
The LD _ (50) of Potassium cinnamate was 5.58-6.78 G / kg, which was a non-toxic product. Potassium cinnamate is absorbed by the body and converted into L-Phenylalanine acid. It is metabolized out of the body. A small amount of L-Phenylalanine acid can be Pah to form tyrosine without any toxicity to the body. Its active preservative, cinnamic acid, was identified as Gras (generally considered safe) by FEMA in 1965.
The effective preservative of potassium cinnamate is also a natural inducer of differentiation for many kinds of cells That is, anti-fatigue, promote metabolism, anti-inflammatory, anti-cancer, vasodilator, maintain excitement and blood pressure, and other health functions.
Potassium cinnamate(CAS: 16089-48-8) is a kind of natural cinnamon extract, which is widely used in food because of its good solubility. The mechanism of preservation is that potassium cinnamate is converted into cinnamic acid under acid conditions. Cinnamic acid is a weak acid whose PKA is between 4.37 and 4.44. Its anti-microbial effect depends on the form of mostly unionized acid molecules. When dissolved in water, weak acids do not ionize completely into ions but form a balance between charged and ionic forms and uncharged and unionized forms.
The two forms are proportional to the Ph of the solution. The more acidic the solution, the more non-ionized forms. Since the 1950s, it has been known that cinnamic acid works by inhibiting the use of L-Phenylalanine and tyrosine by microorganisms. In its non-ionized form, cinnamic acid as a weak acid preservative is considered to be soluble in microbial membranes, enter cells, ionize at a higher Ph and thus reduce the internal Ph, which can effectively affect the activity of many important enzymes So it eventually kills the contaminated cells.
Potassium cinnamate has an anti-tumor effect and anti-mutagenic activity in vitro. It can inhibit all kinds of tumors induced by carcinogens in rodents. Studies have found that cinnamic acid, the active ingredient in potassium cinnamate, inhibits the proliferation of cell lines such as Glioblastoma multiforme, melanoma, and hormone insensitive prostate cancer It can reverse the malignant phenotype of highly metastatic human lung cancer cells and inhibit the invasion.
It can induce the differentiation of human lung Adenocarcinoma Cells, human liver cancer cells, human promyelocytic leukemia cells, etc. Cinnamic acid is an effective inhibitor of A-5491 human lung adenocarcinoma cells, which has great potential application value in anti-cancer, can increase the content of white blood cells, anti-radiation There are anti-tumor, lung cancer, tuberculosis.
KANG-BEOM KWON ET AL had no significant effect on the blood glucose level of the normal control mice after administration of Potassium cinnamate for 7 days. The mice in the treatment group had significant hypoglycemic effects The Blood Glucose level of the high, middle, and low dose group decreased in turn, which was a dose-effect relationship. The plasma insulin level also increased significantly (compared with the control group (p 0.01), showing a dose-effect relationship.
Diabetes is a common endocrine and metabolic disease, often accompanied by Lipid Metabolic disorders and hyperlipidemia. Long-term hyperglycemia and hyperlipemia are easy to induce diabetic cardio-cerebral vascular disease. In the treatment of diabetes, lowering blood lipids is almost as important as lowering blood glucose. The results of many experiments show that potassium cinnamate can reduce blood lipid as well as blood glucose, suggesting that potassium cinnamate plays a certain role in the prevention and treatment of diabetes and its complications.