May. 21, 2021
Carbamates and their derivatives have been found in fruits, vegetables, and whole grains. Carbamic acid and its derivatives have been found in fruits, vegetables, and whole grains. The potential of cinnamic acid in the treatment of diabetes has been highlighted in a new review, but concerns about bioavailability continue to hinder its use in healthy foods. Next, the cinnamic acid supplier will share with you.
Cinnamic acid and its derivatives are naturally present in a large number of plant-based foods. Among the various biological activities, cinnamic acid and its derivatives are related to beneficial effects on diabetes and its complications.
Cinnamic acid and its derivatives are found in fruits, vegetables, and whole grains. It can also be obtained from cinnamon, coffee, tea, and cocoa. Several mechanisms have been proposed to explain the beneficial effects of cinnamic acid on diabetes and its complications, the review said. It has previously been studied how it stimulates insulin secretion, which is needed to improve glucose tolerance.
The review said: ``In a rat study, cinnamic acid was found to be an inactive insulin-secreting compound in INS-1 pancreatic B cells.''
Another rat study noted that cinnamic acid has anti-diabetic effects, increasing glucose tolerance in vivo and stimulating insulin secretion in vitro.
Oral administration of cinnamic acid (5 and 10 mg) significantly improved glucose tolerance in diabetic rats. These findings suggest that cinnamic acid exerts antidiabetic activity by improving glucose tolerance and insulin secretion.
Meanwhile, another study found synergistic effects of cinnamic acid and its derivatives (cinnamic acid, ferulic acid, p-hydroxycinnamic acid, and caffeic acid) when combined with the oral hypoglycemic agent's metformin and thiazolidinedione.
"In combination with oral hypoglycemic agents, ferulic acid, caffeic acid, and p-hydroxycinnamic acid interacted synergistically with metformin and thiazolidinedione, while cinnamic acid exhibited a cumulative effect on glucose uptake," the evaluation noted.
Combination therapy between compounds and oral hypoglycemic agents can improve beneficiary activity and the drug load reduction in patients.
While the study suggests that cinnamic acid has the potential in helping to prevent and control diabetes and its complications, the review says there is no clinical evidence yet of the beneficial effects of this plant-based compound.
Further epidemiological studies are needed to assess the role of cinnamic acid and its derivatives in the prevention and control of diabetes mellitus and its complications. The pharmacokinetics of these compounds are of major concern, especially the low bioavailability. Therefore, the use of cinnamic acid and its derivatives in the field of medicinal and nutritional products remains limited.
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