How Much Do You Know About ​Cinnamic Acid?

Aug. 15, 2022

Cinnamic acid can be defined as an organic compound that consists of an acrylic acid group containing a substituent of phenyl at the third position of the. It is a monocarboxylic acid. Cinnamic acid is commonly found in cinnamon oil and shea butter. The cinnamic acid formula can be represented as C9H8O2. The chemical compound has a white-colored crystalline appearance it is highly soluble in organic solvents.


Other Names of the Chemical Compound

The cinnamic acid IUPAC name is (2E)-3-Phenylprop-2-enoic acid. The other common names of the compound include the following.


Cinnamic acid

Trans-Cinnamic acid

Phenylacrylic acid


3-Phenylacrylic acid

(E)-Cinnamic acid

Benzenepropenoic acid

Isocinnamic acid

Cinnamic Acid

 Cinnamic Acid          

Preparation of Cinnamic Acid

There are various methods of preparation of cinnamic acid, the most commonly used industrial method is the Perkin reaction, another common way of synthesis of cinnamic acid involves the Knoevenagel condensation, in this reaction the reactants benzaldehyde and malonic acid in the presence of a weak base undergo acid-catalyzed decarboxylation.


Uses of Cinnamic Acid

There are the following uses of the compound. They are listed below


  • They are used as flavoring agents

  • It is used in the production of indigo

  • It is also used in the production of some pharmaceuticals

  • It is used as a major ingredient in the perfume industry because it serves as a precursor of the following compounds used in the production of scent, methyl cinnamate, ethyl cinnamate, and benzyl cinnamate.


Cinnamic acid is commonly used as a flavor compound in food and beverages and for its aroma in perfumes and cosmetics. Cinnamic acid is naturally present in the spice cinnamon, which is derived from the bark of the genus Cinnamomum. The main aromatic compound in the flavor of cinnamon is cinnamaldehyde. Cinnamic acid also acts as a component of the lignin unit, which is synthesised from phenylalanine. As mentioned above, microorganisms can also be exposed to cinnamic acid through lignin degradation and chemosensitization.


Cinnamic Acid

Cinnamic Acid    


Other potential health benefits.

Studies have shown that cinnamic acid may also have other health benefits.


It may treat periodontitis. Periodontitis is an inflammation of the gum tissue, and periodontal disease is associated with cardiovascular, endocrine and reproductive disorders. A study in rats found that cinnamic acid reduced inflammation caused by periodontitis and promote bone growth in the area.


Potential cancer treatment. Studies have shown that cinnamic acid and its derivatives can inhibit oncogenic proteins and may be an adjuvant therapy for the treatment of lung and breast cancers.


May provide UV protection. Cinnamic acid is a common ingredient in many cosmetic products used to provide UV protection. Cinnamic acid is sensitive to and activated by UV radiation and has antioxidant properties.


It can reduce the risk of dengue fever. Some derivatives of cinnamic acid have larvicidal properties and have been shown to destroy the larvae of the Aedes aegypti mosquito, which transmits dengue, yellow fever, chikungunya, and Zika viruses.


In summary

Cinnamic acid has been associated with various health benefits and may support gut health and memory. It may help prevent neurodegenerative diseases, diabetes, cancer, and periodontal disease. However, more research is needed.